This is a very difficult question for me, and I suspect for most of us. Sure, I can name a few generalities (better health, more money, more time to connect with my family, a job more in line with my professional training), but to name a specific goal and identify the steps necessary to accomplish it is daunting.
After some thought, though, I know the one specific thing I want to accomplish this year. I'm going to publish a book. Not just any "I won NaNoWriMo, now it's time to hit KDP" book, but a book with professional editing and cover design that I can look back on in 20 years and still be proud to call my first.
You know what? It's true. If you can name the thing you want, you can see the path you need to walk to get there.